USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: SRC8_HUMAN USC-OGP 2-DE database:  SRC8_HUMAN SRC8_HUMAN General information about the entry View entry in simple text format Entry name SRC8_HUMAN Primary accession number Q14247 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Src substrate cortactin; AltName: Full=Amplaxin; AltName: Full=Oncogene EMS1;. Gene name Name=CTTN Synonyms=EMS1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0308: pI=5.14; Mw=72383 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1118: pI=5.28; Mw=86732 Cross-references UniProtKB/Swiss-Prot Q14247; SRC8_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SRC8_HUMAN Primary accession number Q14247 Secondary accession number(s) Q8N707 Q96H99 Sequence was last modified on  November 25, 2008 (version 2) Annotations were last modified on  March 15, 2017 (version 179) Name and origin of the protein Description RecName: Full=Src substrate cortactin; AltName: Full=Amplaxin; AltName: Full=Oncogene EMS1; Gene name Name=CTTN Synonyms=EMS1 Encoded on Name=CTTN; Synonyms=EMS1 Keywords 3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Cell projection; Coated pit; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endocytosis; Isopeptide bond; Membrane; Methylation; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M98343; AAA58455.1; -; mRNA EMBL AK291097; BAF83786.1; -; mRNA EMBL AP000487; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471076; EAW74766.1; -; Genomic_DNA EMBL CH471076; EAW74768.1; -; Genomic_DNA EMBL BC008799; AAH08799.1; -; mRNA EMBL BC033889; AAH33889.1; -; mRNA CCDS CCDS41680.1; -. [Q14247-1]; . CCDS CCDS53676.1; -. [Q14247-2]; . CCDS CCDS8197.1; -. [Q14247-3]; . PIR A48063; A48063; . RefSeq NP_001171669.1; NM_001184740.1. [Q14247-2]; . RefSeq NP_005222.2; NM_005231.3. [Q14247-1]; . RefSeq NP_612632.1; NM_138565.2. [Q14247-3]; . UniGene Hs.596164; -; . PDB 1X69; NMR; -; A=485-550 PDB 2D1X; X-ray; 1.90 A; A/B/C/D=490-550 PDBsum 1X69; -; . PDBsum 2D1X; -; . ProteinModelPortal Q14247; -; . SMR Q14247; -; . BioGrid 108332; 115; . DIP DIP-33190N; -; . IntAct Q14247; 67; . MINT MINT-361929; -; . iPTMnet Q14247; -; . PhosphoSitePlus Q14247; -; . SwissPalm Q14247; -; . BioMuta CTTN; -; . DMDM 215273892; -; . OGP Q14247; -; . EPD Q14247; -; . MaxQB Q14247; -; . PeptideAtlas Q14247; -; . PRIDE Q14247; -; . DNASU 2017; -; . Ensembl ENST00000301843; ENSP00000301843; ENSG00000085733. [Q14247-1]; . Ensembl ENST00000346329; ENSP00000317189; ENSG00000085733. [Q14247-3]; . Ensembl ENST00000376561; ENSP00000365745; ENSG00000085733. [Q14247-2]; . GeneID 2017; -; . KEGG hsa:2017; -; . UCSC uc001opu.4; human. [Q14247-1]; . CTD 2017; -; . DisGeNET 2017; -; . GeneCards CTTN; -; . HGNC HGNC:3338; CTTN; . HPA CAB011235; -; . HPA HPA057242; -; . MIM 164765; gene; . neXtProt NX_Q14247; -; . OpenTargets ENSG00000085733; -; . PharmGKB PA27775; -; . GeneTree ENSGT00530000062953; -; . HOGENOM HOG000006523; -; . HOVERGEN HBG005994; -; . InParanoid Q14247; -; . KO K06106; -; . OMA KDYSDGF; -; . OrthoDB EOG091G0CPX; -; . PhylomeDB Q14247; -; . TreeFam TF318935; -; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . SIGNOR Q14247; -; . ChiTaRS CTTN; human; . EvolutionaryTrace Q14247; -; . GeneWiki Cortactin; -; . GenomeRNAi 2017; -; . PRO PR:Q14247; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000085733; -; . CleanEx HS_CTTN; -; . ExpressionAtlas Q14247; baseline and differential; . Genevisible Q14247; HS; . GO GO:0005938; C:cell cortex; IDA:UniProtKB; . GO GO:0005905; C:clathrin-coated pit; ISS:UniProtKB; . GO GO:0030863; C:cortical cytoskeleton; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005856; C:cytoskeleton; TAS:ProtInc; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; IDA:HPA; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0030027; C:lamellipodium; IDA:UniProtKB; . GO GO:1990023; C:mitotic spindle midzone; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0002102; C:podosome; IEA:UniProtKB-SubCell; . GO GO:0001726; C:ruffle; ISS:UniProtKB; . GO GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005522; F:profilin binding; IPI:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB; . GO GO:0030041; P:actin filament polymerization; IEA:InterPro; . GO GO:0048870; P:cell motility; ISS:UniProtKB; . GO GO:0097062; P:dendritic spine maintenance; IEA:Ensembl; . GO GO:0048041; P:focal adhesion assembly; ISS:UniProtKB; . GO GO:0006886; P:intracellular protein transport; IMP:UniProtKB; . GO GO:0097581; P:lamellipodium organization; ISS:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB; . GO GO:0030838; P:positive regulation of actin filament polymerization; IMP:UniProtKB; . GO GO:0045987; P:positive regulation of smooth muscle contraction; IMP:UniProtKB; . GO GO:0006898; P:receptor-mediated endocytosis; ISS:UniProtKB; . GO GO:0030516; P:regulation of axon extension; ISS:UniProtKB; . GO GO:1903146; P:regulation of mitophagy; IEA:Ensembl; . GO GO:0006930; P:substrate-dependent cell migration; cell extension; IEA:Ensembl InterPro IPR015503; Cortactin; . InterPro IPR003134; Hs1_Cortactin; . InterPro IPR001452; SH3_domain; . PANTHER PTHR10829:SF37; PTHR10829:SF37; 1; . Pfam PF02218; HS1_rep; 7; . Pfam PF14604; SH3_9; 1; . PRINTS PR00452; SH3DOMAIN; . SMART SM00326; SH3; 1; . SUPFAM SSF50044; SSF50044; 1; . PROSITE PS51090; CORTACTIN; 7; . PROSITE PS50002; SH3; 1; .

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